Syn-selective kobayashi aldol reaction using the E,E-vinylketene silyl N,O -acetal

Yuki Mukaeda, Takuya Kato, Seijiro Hosokawa

研究成果: Article査読

32 被引用数 (Scopus)

抄録

The Kobayashi aldol reaction is one of the most powerful methods to synthesize the polyketide skeleton and has been applied to the total synthesis of natural products. This methodology has been used to construct anti-aldol products, and only a few precedents on the syn-selective Kobayashi aldol reaction are known. A syn-selective Kobayashi aldol reaction by using the E,E-vinylketene silyl N,O-acetal and an excess amount of Lewis acid is presented.

本文言語English
ページ(範囲)5298-5301
ページ数4
ジャーナルOrganic Letters
14
20
DOI
出版ステータスPublished - 2012 10 19

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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