Syn selective vinylogous mukaiyama aldol reaction using Z,EVinylketene N,O-acetal with acetals

Naoya Sagawa, Hiroki Moriya, Seijiro Hosokawa

    研究成果: Article

    11 引用 (Scopus)

    抜粋

    Stereoselective vinylogous Mukaiyama aldol reactions using the Z,E-vinylketene silyl N,O-acetal possessing a chiral auxiliary, derived from (E)-3-pentenoic acid and Lvaline, have been achieved. The reaction proceeded smoothly to give a syn adduct in high stereoselectivity. Since the products possess structures including δ-alkoxy-γ-methyl-α,β-unsaturated imide, this reaction would be applicable to synthesize polyketides in a short procedure.

    元の言語English
    ページ(範囲)250-253
    ページ数4
    ジャーナルOrganic Letters
    19
    発行部数1
    DOI
    出版物ステータスPublished - 2017 1 1

    ASJC Scopus subject areas

    • Biochemistry
    • Physical and Theoretical Chemistry
    • Organic Chemistry

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