Synaptic function and neuropathological disease revealed by quantum dot-single-particle tracking

Hiroko Bannai, Takafumi Inoue, Matsumi Hirose, Fumihiro Niwa, Katsuhiko Mikoshiba

研究成果: Chapter

1 引用 (Scopus)

抜粋

Quantum dot-single-particle tracking (QD-SPT) is a super-resolution imaging technique that uses semiconductor nanocrystal quantum dots as fluorescent probes and is a powerful tool for analyzing protein and lipid behavior in the plasma membrane. Recent QD-SPT experiments have provided critical insight into the mechanism and physiological relevance of membrane self-organization in neurons and astrocytes in the brain. The mobility of some membrane molecules may become abnormal in cellular models of epilepsy and Alzheimer’s disease. Based on these findings, we propose that the behavior of membrane molecules reflects the condition of neurons in pathological disease states. In this chapter, we describe the latest, simple QD-SPT technique, which is feasible with epifluorescence microscopy and dissociated cell cultures.

元の言語English
ホスト出版物のタイトルNeuromethods
出版者Humana Press Inc.
ページ131-155
ページ数25
DOI
出版物ステータスPublished - 2020

出版物シリーズ

名前Neuromethods
154
ISSN(印刷物)0893-2336
ISSN(電子版)1940-6045

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Psychiatry and Mental health

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  • これを引用

    Bannai, H., Inoue, T., Hirose, M., Niwa, F., & Mikoshiba, K. (2020). Synaptic function and neuropathological disease revealed by quantum dot-single-particle tracking. : Neuromethods (pp. 131-155). (Neuromethods; 巻数 154). Humana Press Inc.. https://doi.org/10.1007/978-1-0716-0532-5_7