Synchronized stereocontrol of planar chirality by crystallization-induced asymmetric transformation

Nobuhiro Kanomata, Gou Mishima, Jun Onozato

研究成果: Article

16 引用 (Scopus)

抜粋

Synchronized stereocontrol of two planar-chiral units was accomplished by using crystallization-induced asymmetric transformation (CIAT) of cyclophane-type bridged bisnicotinate derivatives 5b and 7. After screening various linkers, (S)-2-amino-1-butanol and (S)-tert-leucinol were found to be the most effective for CIAT of the corresponding bridged bisnicotinate 5b and 7, respectively, whose diastereomeric ratio finally reached 97% and 88%, respectively.

元の言語English
ページ(範囲)409-412
ページ数4
ジャーナルTetrahedron Letters
50
発行部数4
DOI
出版物ステータスPublished - 2009 1 28

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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