Synergistic Inhibition of Fructose 1,6‐Bisphosphatase by Fructose 2,6‐Bisphosphate and Adenosine Monophosphate in Round Spermatids of Rats: fructose 1, 6‐bisphosphatase/AMP/fructose 2, 6‐bisphosphate/spermatids/rats

MASAHISA NAKAMURA, AKIRA SUZUKI, SHOICHI OKINAGA, KIYOSHI ARAI

研究成果: Article

抜粋

The effects of adenosine monophosphate (AMP) and fructose 2, 6‐bisphosphate (fruc‐2, 6‐P2) on the key‐enzyme of gluconeogenesis, fructose 1, 6‐bisphosphatase (fruc‐P2ase; D‐fructose 1, 6‐bisphosphate 1‐phosphohydrolase, EC 3.1.3.11) in spermatid extract from rat testes were studied. The fruc‐P2ase activity in the spermatids of rats was suppressed by AMP and fruc‐2, 6‐P2. The inhibition of fruc‐2, 6‐P2 was much stronger at low than at high substrate concentrations, and enhanced synergistically with AMP. The substrate saturation curve was changed by fruc‐2, 6‐P2 hyperbolic to sigmoidal. Furthermore, the concentration of AMP that decreased the activity to 50% was much lower in the presence than in the absence of fruc‐2, 6‐P2. These results indicate the possibility that gluconeogenesis in spermatids of rats is controlled by AMP and fruc‐2, 6‐P2.

元の言語English
ページ(範囲)497-502
ページ数6
ジャーナルDevelopment Growth and Differentiation
26
発行部数5
DOI
出版物ステータスPublished - 1984
外部発表Yes

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

フィンガープリント Synergistic Inhibition of Fructose 1,6‐Bisphosphatase by Fructose 2,6‐Bisphosphate and Adenosine Monophosphate in Round Spermatids of Rats: fructose 1, 6‐bisphosphatase/AMP/fructose 2, 6‐bisphosphate/spermatids/rats' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

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