Syntheses and Biological Activities of Selenium Analogs of α-Rat Atrial Natriuretic Peptide1)

Takaki Koide, Hiromi Itoh, Akira Otaka, Nobutaka Fuji, Mayumi Furuya, Yasuo Kitajima

研究成果: Article査読

15 被引用数 (Scopus)

抄録

a-Rat atrial natriuretic peptide (7—28) (rANP (7—28)) and a series of its analogs in which half cystine residue(s) were substituted with half selenocystine residue(s) were synthesized by using the Fmoc-based solid-phase method followed by cyclization by means of dimethylsulfoxide (DMSO)-trifluoroacetic acid (TFA) oxidation. These analogs possess comparable activities in both receptor binding and cGMP accumulation in rat vascular smooth muscle cells to those of rAMP (7—28).

本文言語English
ページ(範囲)1596-1600
ページ数5
ジャーナルChemical and Pharmaceutical Bulletin
41
9
DOI
出版ステータスPublished - 1993
外部発表はい

ASJC Scopus subject areas

  • 化学 (全般)
  • 創薬

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