Syntheses of Biologically Active 2-Arylcyclopropylamines

Shin Miyamura, Kenichiro Itami, Junichiro Yamaguchi

研究成果: Review article査読

11 被引用数 (Scopus)

抄録

The 2-arylcyclopropylamine (ACPA) motif is often seen in biologically active compounds. This review focuses on the synthesis of biologically active ACPAs and categorizes, by reaction type, the synthetic methods used toward such compounds. 1 Introduction 2 Cyclopropanation Using Diazo Compounds 2.1 Styrene 2.2 Cinnamate 2.3 Vinyl Phthalimide 2.4 Vinyl Acetamide 2.5 Oxazolone 2.6 Diketopiperazine 3 Cyclopropanation Using Ylides 3.1 Cinnamate 3.2 Nitrostyrene 3.3 Oxirane 3.4 Nitroacetate 4 Transformation of Cyclopropanes 4.1 Iodocyclopropane 4.2 Aminocyclopropane 5 Miscellaneous Methods 5.1 Kulinkovich Reaction 5.2 Three-Component Reaction 5.3 Intramolecular Nucleophilic Cyclization 5.4 Intramolecular Mitsunobu Reaction 5.5 Rearrangement from Cyclobutanone 6 Summary.

本文言語English
論文番号ss-2016-e0599-r
ページ(範囲)1131-1149
ページ数19
ジャーナルSynthesis (Germany)
49
6
DOI
出版ステータスPublished - 2017 3 15

ASJC Scopus subject areas

  • Catalysis
  • Organic Chemistry

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