Syntheses of fumagillin and ovalicin

Junichiro Yamaguchi, Yujiro Hayashi*

*この研究の対応する著者

研究成果: Review article査読

23 被引用数 (Scopus)

抄録

(Figure Presented) This review focuses on the synthetic strategies used for the construction of fumagillin, ovalicin, and other natural products of this family that are known angiogenesis inhibitors. These compounds are comprised of a cyclohexane framework, two epoxides, and five or six contiguous stereogenic centers. The first total syntheses of fumagillin and ovalicin were reported by Corey in 1972 and 1985, respectively. There were numerous studies directed at these natural products in the decades that followed with many reports appearing in the year 2000 or later. Despite the relatively small size of these molecules, their syntheses highlight the efficient construction of stereogenic centers in organic synthesis.

本文言語English
ページ(範囲)3884-3901
ページ数18
ジャーナルChemistry - A European Journal
16
13
DOI
出版ステータスPublished - 2010 4月 6
外部発表はい

ASJC Scopus subject areas

  • 触媒
  • 有機化学

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