抜粋
The core structure of cristaxenicin A having trans-fused dihydropyran and nine membered ring has been synthesized and evaluated the antileishmanial activity. The dihydropyran ring was synthesized by [4+2] cycloaddition reaction between an unsaturated aldehyde and a β-alkoxy-α,β-unsaturated ketone. The nine membered ring possessing α,β-unsaturated aldehyde was constructed by the intramolecular NHK reaction followed by the Mitsunobu rearrangement. The racemic core structure of cristaxenicin A was evaluated the anti-leishmanial activity with an IC50 value of 2.4 μM.
| 元の言語 | English |
|---|---|
| ページ（範囲） | 4355-4357 |
| ページ数 | 3 |
| ジャーナル | Bioorganic and Medicinal Chemistry Letters |
| 巻 | 26 |
| 発行部数 | 17 |
| DOI | |
| 出版物ステータス | Published - 2016 9 1 |
ASJC Scopus subject areas
- Biochemistry
- Molecular Medicine
- Molecular Biology
- Pharmaceutical Science
- Drug Discovery
- Clinical Biochemistry
- Organic Chemistry
フィンガープリント Synthesis and antileishmanial activity of the core structure of cristaxenicin A' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。
これを引用
Fumiyama, H., Sadayuki, T., Osada, Y., Goto, Y., Nakao, Y., & Hosokawa, S. (2016). Synthesis and antileishmanial activity of the core structure of cristaxenicin A. Bioorganic and Medicinal Chemistry Letters, 26(17), 4355-4357. https://doi.org/10.1016/j.bmcl.2016.06.061