@article{ca26be2434e94e4b90771744f1f2fa74,
title = "Synthesis and antileishmanial activity of the core structure of cristaxenicin A",
abstract = "The core structure of cristaxenicin A having trans-fused dihydropyran and nine membered ring has been synthesized and evaluated the antileishmanial activity. The dihydropyran ring was synthesized by [4+2] cycloaddition reaction between an unsaturated aldehyde and a β-alkoxy-α,β-unsaturated ketone. The nine membered ring possessing α,β-unsaturated aldehyde was constructed by the intramolecular NHK reaction followed by the Mitsunobu rearrangement. The racemic core structure of cristaxenicin A was evaluated the anti-leishmanial activity with an IC50value of 2.4 μM.",
keywords = "Antileishmanial, Cristaxenicin A, Nine-membered ring, Synthesis, [4+2] cycloaddition",
author = "Hitoshi Fumiyama and Tomoko Sadayuki and Yasutaka Osada and Yasuyuki Goto and Yoichi Nakao and Seijiro Hosokawa",
note = "Funding Information: Authors are grateful for financial support to The Kurata Memorial Hitachi Science and Technology Foundation and The Naito Foundation . This Letter is a part of the outcome of research performed under a Waseda University Grant for Special Research Projects (Project number: 2008A-059). Publisher Copyright: {\textcopyright} 2016 Elsevier Ltd",
year = "2016",
doi = "10.1016/j.bmcl.2016.06.061",
language = "English",
volume = "26",
pages = "4355--4357",
journal = "Bioorganic and Medicinal Chemistry Letters",
issn = "0960-894X",
publisher = "Elsevier Limited",
number = "17",
}