抄録
The design, synthesis, and bioevaluation of fluorescence- and biotin-labeled CXCR4 antagonists are described. The modification of D-Lys8 at an ε-amino group in the peptide antagonist Ac-TZ14011 derived from polyphemusin II had no significant influence on the potent binding of the peptide to the CXCR4 receptor. The application of the labeled peptides in flow cytometry and confocal microscopy studies demonstrated the selectivity of their binding to the CXCR4 receptor, but not to CXCR7, which was recently reported to be another receptor for stromal cell-derived factor 1 (SDF-1)/CXCL12.
本文言語 | English |
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ページ(範囲) | 1154-1158 |
ページ数 | 5 |
ジャーナル | ChemBioChem |
巻 | 9 |
号 | 7 |
DOI | |
出版ステータス | Published - 2008 5月 5 |
外部発表 | はい |
ASJC Scopus subject areas
- 生化学
- 分子医療
- 分子生物学
- 有機化学