Synthesis and structure - anti-tumor-promoting activity relationship of monogalactosyl diacylglycerols

Akito Nagatsu, Miyako Watanabe, Kouji Ikemoto, Masayo Hashimoto, Nobutoshi Murakami, Jinsaki Sakakibara, Harukuni Tokuda, Hoyoku Nishino, Akio Iwashima, Kazunaga Yazawa

研究成果: Article査読

38 被引用数 (Scopus)

抄録

Monogalactosyl diacylglycerols (MGDG, 1a-t) were synthesized utilizing p-methoxybenzyl group for protection of hydroxyl groups at sugar moiety. Inhibitory activity of MGDG (1a-t) and related compounds on Epstein-Barr virus early antigen activation was evaluated as anti-tumor-promoting activity, and MGDG with oleoyl group (1c,h-j,p,s) showed strong activity.

本文言語English
ページ(範囲)1619-1622
ページ数4
ジャーナルBioorganic and Medicinal Chemistry Letters
4
13
DOI
出版ステータスPublished - 1994 7 7
外部発表はい

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

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