Synthesis, characterization and cytotoxicity evaluation on zinc doped hydroxyapatite in collagen matrix

C. L. Popa, C. M. Bartha, M. Albu, R. Guegan, M. Motelica-Heino, M. C. Chifiriuc, C. Bleotu, M. L. Badea, S. Antohe*

*この研究の対応する著者

研究成果: Article査読

10 被引用数 (Scopus)

抄録

The goal of this study was to obtain at low temperature a functional nano-composite with characteristics similar to the natural bone by using a cost effective method. The structure and morphology of collagen coated zinc doped hydroxyapatite bio-composites (Zn:HAp-CBc) were examined by X-Ray diffraction (XRD) and Scanning Electron Microscopy (SEM). XRD analysis revealed that the unique hexagonal Ca10(PO4)6(OH)2 in P63m space group was observed in the obtained nanocomposites Zn:HAp-CBc. The cytotoxicity of the Zn:HAp-CBc was studied on HeLa cell lines. Cell cycle distribution after treatment was examined by flow cytometry analysis. Our preliminary in vitro studies revealed that the obtained composites based on Zn doped HAp embedded in collagen matrix have excellent biocompatibility and support their further characterization by in vivo approaches and development as a biomaterial used in bone regeneration.

本文言語English
ページ(範囲)681-691
ページ数11
ジャーナルDigest Journal of Nanomaterials and Biostructures
10
2
出版ステータスPublished - 2015
外部発表はい

ASJC Scopus subject areas

  • 構造生物学
  • 原子分子物理学および光学
  • 生体医工学
  • 材料科学(全般)
  • 凝縮系物理学
  • 物理化学および理論化学

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