Synthesis of α-fluoroketones based on palladium-catalyzed Decarboxylation reactions of allyl β-keto carboxylates

Isao Shimizu, Hirotoshi Ishii

研究成果: Article査読

25 被引用数 (Scopus)

抄録

Fluorination of allyl β-keto carboxylates using N-fluoro-2,4,6-pyridinium triflate gave allyl α-fluoro-β-keto carboxylates. Reaction of allyl α-fluoro-β-keto carboxylates with formic acid in the presence of palladium-phosphine catalyst gave α-fluoro ketones. When the palladium-catalyzed reaction was carried out without formic acid, the decarboxylation-allylation took place to give α-fluoro-allylketones. Decarboxylation-dehydrogenation to afford α-fluoro-α,β-unsaturated ketones was carried out with palladium catalysts in acetonitrile.

本文言語English
ページ(範囲)487-495
ページ数9
ジャーナルTetrahedron
50
2
DOI
出版ステータスPublished - 1991

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

フィンガープリント 「Synthesis of α-fluoroketones based on palladium-catalyzed Decarboxylation reactions of allyl β-keto carboxylates」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル