@article{fd327e4490fc435a9a58f67471ac209b,
title = "Synthesis of a heptaarylisoquinoline: Unusual disconnection for constructing isoquinoline frameworks",
abstract = "In a novel disconnection of isoquinoline ring synthesis at the C7C8/C4aC8a bonds, these bonds can be formed by a [4+2] cycloaddition between thiophene S,S-dioxide and alkynes. With a subsequent CH arylation of the resulting hexaarylisoquinoline at the C3 position, the synthesis of a fully substituted isoquinoline has been achieved.",
keywords = "Heterocycle, Isoquinoline, [4+2] cycloaddition",
author = "Takashi Asako and Shin Suzuki and Kenichiro Itami and Kei Muto and Junichiro Yamaguchi",
note = "Funding Information: This work was supported by JSPS KAKENHI Grant Number JP18H04428, JP18H04272, JP16H04148 (to J. Y.), the ERATO program from JST (to K. I.), and a JSPS research fellowship for young scientists (to S. S.). We thank Dr. Yoshihiro Ishihara (Vertex Pharmaceuticals) for fruitful discussion and critical comments. Materials Characterization Central Laboratory at Waseda University is acknowledged for HRMS measurement. Publisher Copyright: {\textcopyright} 2018 The Chemical Society of Japan.",
year = "2018",
doi = "10.1246/cl.180429",
language = "English",
volume = "47",
pages = "968--970",
journal = "Chemistry Letters",
issn = "0366-7022",
publisher = "Chemical Society of Japan",
number = "8",
}