TY - CONF
T1 - Synthesis of alkylsulfonio-porphyrin complexes and its anti-cancer and anti-oxidant properties
AU - Komuro, Masayasu
AU - Awa, Ryota
AU - Ito, Yuji
AU - Yamaguchi, Aritomo
AU - Oyaizu, Kenichi
AU - Yuasa, Makoto
PY - 2005
Y1 - 2005
N2 - In living body, oxygen (O2) generates reactives oxygen species (ROS) such as superoxide anion radical (O2- ·). Living body has superoxide dismutase (SOD) enzyme for elimination of ROS. However, decrese of activity of SOD causes inflammation, cancer, and other deseases. In this study, we synthesized metalloporphyrins as anti-oxidant and anti-cancer drug. Novel alkylsulfonioporphyrin complexes were synthesized. It was revealed that they were effective as anti-oxidant and as anti-cancer agents, by stopped-flow method and cell viability tests, respectively.
AB - In living body, oxygen (O2) generates reactives oxygen species (ROS) such as superoxide anion radical (O2- ·). Living body has superoxide dismutase (SOD) enzyme for elimination of ROS. However, decrese of activity of SOD causes inflammation, cancer, and other deseases. In this study, we synthesized metalloporphyrins as anti-oxidant and anti-cancer drug. Novel alkylsulfonioporphyrin complexes were synthesized. It was revealed that they were effective as anti-oxidant and as anti-cancer agents, by stopped-flow method and cell viability tests, respectively.
KW - Alkylsulfonioporphyrin
KW - Anti-cancer
KW - Anti-oxidant
KW - SOD model
UR - http://www.scopus.com/inward/record.url?scp=33645650016&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33645650016&partnerID=8YFLogxK
M3 - Paper
AN - SCOPUS:33645650016
SP - 2288
T2 - 54th SPSJ Annual Meeting 2005
Y2 - 25 May 2005 through 27 May 2005
ER -
