Synthesis of C3-C21 Segment of Aflastatin A Using Remote Asymmetric Induction Reactions

Sawato Murakoshi, Seijiro Hosokawa

研究成果: Article査読

1 被引用数 (Scopus)

抄録

The C3-C21 segment of aflastatin A has been synthesized by converging three segments including the C3-C8 segment, the C9-C15 segment, and the C16-C21 segment. Each segment has been synthesized from a vinylketene silyl N,O-acetal possessing a chiral auxiliary by a wide-range stereocontrol strategy. The C3-C8 segment was constructed in seven steps including the stereoselective vinylogous Mukaiyama alkylation, while the C9-C15 segment and the C16-C21 segment were synthesized using the vinylogous Mukaiyama aldol reaction in seven and eight steps, respectively.

本文言語English
ページ(範囲)758-761
ページ数4
ジャーナルOrganic Letters
21
3
DOI
出版ステータスPublished - 2019 2 1

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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