Synthesis of cobalt ferrite nanoparticles using spermine and their effect on death in human breast cancer cells under an alternating magnetic field

Shofu Matsuda, Takuya Nakanishi, Kisako Kaneko, Tetsuya Osaka

研究成果: Article査読

18 被引用数 (Scopus)

抄録

To compare heat generation under an AC magnetic field for inducing cancer cell death, CoFe2O4 and Fe3O4 nanoparticles with a diameter of ∼10 nm were synthesized by hydrolysis in an aqueous solution containing the metal chlorides iron(III) chloride and cobalt(II) or iron(II) chloride, with spermine or N,N'-bis(3-aminopropyl)butane-1,4-diamine, as a base and a protective reagent. Both CoFe2O4 and Fe3O4 nanoparticles were incorporated into human breast cancer MCF-7 cells; the nanoparticles exhibited little toxicity on the cells. When the cells containing nanoparticles were subjected to an AC magnetic field, MCF-7 cell death was induced by heat generated from ∼10-nm CoFe2O4 nanoparticles but not from ∼10-nm Fe3O4 nanoparticles. An increase in coercivity derived from the substitution of Fe2+ with Co2+ facilitated the ability of the nanoparticles to induce cell death in human breast cancer cells under an AC magnetic field.

本文言語English
ページ(範囲)153-159
ページ数7
ジャーナルElectrochimica Acta
183
DOI
出版ステータスPublished - 2015 11 20

ASJC Scopus subject areas

  • Chemical Engineering(all)
  • Electrochemistry

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