Synthesis of fluorescent substrates for protein tyrosine phosphatase assays

Takumi Watanabe; Masaya Imoto; Hiroki Taniguchi; Kazuhiko Kinoshita; Kazuo Umezawa

doi:10.1016/S0960-894X(98)00208-X

Synthesis of fluorescent substrates for protein tyrosine phosphatase assays

Takumi Watanabe, Masaya Imoto, Hiroki Taniguchi, Kazuhiko Kinoshita, Kazuo Umezawa^*

^*この研究の対応する著者

研究成果: Article › 査読

抄録

Two fluorescent substrates for protein tyrosine phosphatase (PTPase) reaction were prepared by conjugation of commercially available O- phosphotyrosine and dansyl chlorides. They were hydrolyzed by CD45 tyrosine phosphatase, and proved to be useful for PTPase assay.

本文言語	English
ページ（範囲）	1301-1302
ページ数	2
ジャーナル	Bioorganic and Medicinal Chemistry Letters
巻	8
号	11
DOI	https://doi.org/10.1016/S0960-894X(98)00208-X
出版ステータス	Published - 1998 6月 2
外部発表	はい

ASJC Scopus subject areas

生化学
分子生物学
有機化学
創薬
薬科学

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10.1016/S0960-894X(98)00208-X

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abstract = "Two fluorescent substrates for protein tyrosine phosphatase (PTPase) reaction were prepared by conjugation of commercially available O- phosphotyrosine and dansyl chlorides. They were hydrolyzed by CD45 tyrosine phosphatase, and proved to be useful for PTPase assay.",

keywords = "Amino acids and derivatives, Enzyme inhibitors, Fluorescence",

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Synthesis of fluorescent substrates for protein tyrosine phosphatase assays

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