This paper describes the synthesis of two polymerizable and amphiphilic porphyrins, and their copolymers with 1,2-bis(2′,4′-octadecadienoyl)-sn-glycero-3-phosphocholine. The two porphyrins and their (porphinato)iron derivatives have high compatibility with phospholipids and are efficiently copolymerized with the polymerizable phospholipid in a liposome state to give polymerized liposomes covalently containing the porphyrin residues. The oxygen-binding property of the copolymerized (porphinato)iron liposome is also described in comparison with that of a red blood cell.
|出版ステータス||Published - 1989 1月|
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