Synthesis of six-coordination proximal base conjugation iron (III) porphyrin complexes and evaluation as a superoxide sensor

Makoto Yuasa, Kenichi Oyaizu, Hidenori Murata, Yujiro Toyoda, Masahiro Namba, Masaki Shitara

研究成果: Article査読

2 被引用数 (Scopus)

抄録

Reactive oxygen species (ROS) such as the superoxide anion radical (O2-•) play an essential role on normal cellular growth and homeostasis. However, excess ROS generated by perturbing O2-• homeostasis under various conditions of oxidative stress induce high radical toxicity, resulting in many diseases such as a cancer, brain and mitocondrial infarction, and inflammation. Therefore, quantitative measurement of O2 1• in vivo is important for clarifying their relationship under various conditions. However, in most cases, the biological significance and mechanism of the O2 1• generation are not well understood yet. We have developed a O21• sensor composed of a thin film of N-methylimidazole-coordinated iron meso-tetra (3-thienyl) porphyrin ((Im)2FeT3ThP) for the electrochemical detection of O2-•. The microsensor displayed high selectivity and activity for the oxidation of O2 -• and showed a linear relationship between electric current and O2-• concentration. In this study, we have designed and synthesized a novel hexa-coordinated iron (III) porphyrin compound, which is more stable than the meso-tetra (3-thienyl) porphyrin coordinating imidazoles. This compound was electropolymerized onto the electrode and used as a O2 -• sensor. The redox potential of the electrode suggests that the molecular structure in the electropolymerized film is maintained. This novel modified electrode displayed a high activity for the oxidation of O2-• even in the presence of H2O2 and showed a linear relationship between the electric current and O2-• concentration.

本文言語English
ページ(範囲)349-354
ページ数6
ジャーナルKOBUNSHI RONBUNSHU
65
5
DOI
出版ステータスPublished - 2008 5
外部発表はい

ASJC Scopus subject areas

  • 化学工学(その他)
  • 材料科学(その他)
  • 環境科学(全般)
  • ポリマーおよびプラスチック

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