Synthesis of Triarylpyridines in Thiopeptide Antibiotics by Using a C-H Arylation/Ring-Transformation Strategy

Kazuma Amaike, Kenichiro Itami, Junichiro Yamaguchi*

*この研究の対応する著者

研究成果: Article査読

35 被引用数 (Scopus)

抄録

We have described a C-H arylation/ring-transformation strategy for the synthesis of triarylpyridines, which form the core structure of thiopeptide antibiotics. This synthetic method readily gave 2,3,6-triarylpyridines in a regioselective manner by a two-phase approach: C-H arylation (a nickel-catalyzed decarbonylative Suzuki-Miyaura cross-coupling and decarbonylative C-H coupling for the synthesis of 2,4-diaryloxazoles) and ring transformation ([4+2] cycloaddition of 2,4-diaryloxazoles with (hetero)arylacrylic acids). To showcase these methods, we have accomplished the formal synthesis of thiopeptide antibiotics GE2270 s and amythiamicins.

本文言語English
ページ(範囲)4384-4388
ページ数5
ジャーナルChemistry - A European Journal
22
13
DOI
出版ステータスPublished - 2016 3 18
外部発表はい

ASJC Scopus subject areas

  • 触媒
  • 有機化学

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