Synthetic studies on (+)-bucidarasin C: Two diastereoselective transannular reactions producing cis-decaline derivatives that show reversal selectivity

Akinobu Nakahara, Misaki Kanbe, Masahisa Nakada

研究成果: Article査読

6 被引用数 (Scopus)

抄録

This manuscript describes studies on the construction of the cis-decaline core of (+)-bucidarasin C. The transannular Diels-Alder (TADA) reaction of a macrocyclic lactone successfully afforded the desired cis-decaline derivative in a stereoselective manner. On the other hand, the stereoselective transannular cascade Michael (TACM) reaction of the parent macrocyclic lactone afforded the diastereomeric cis-decaline derivative as the major product.

本文言語English
ページ(範囲)1518-1522
ページ数5
ジャーナルTetrahedron Letters
53
12
DOI
出版ステータスPublished - 2012 3 21

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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