抄録
Asymmetric synthesis of the spirocyclic CD-ring moiety of (+)-ophiobolin A is described. Fragment A, which was prepared via pig liver esterase (PLE)-mediated kinetic resolution, and fragment B, which was prepared via diastereoselective allylation and subsequent kinetic iodolactonization, were coupled to afford the allylsilane 2, which was successfully cyclized to the desired spirocyclic CD-ring moiety 1a in the presence of a Lewis acid.
本文言語 | English |
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ページ(範囲) | 2039-2042 |
ページ数 | 4 |
ジャーナル | Organic Letters |
巻 | 8 |
号 | 10 |
DOI | |
出版ステータス | Published - 2006 5 11 |
ASJC Scopus subject areas
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry