Synthetic studies on phloroglucins: a new approach to the bicyclo[3.3.1]nonane system via the regioselective ring-opening of the methoxycyclopropane

Masahito Abe, Masahisa Nakada*

*この研究の対応する著者

研究成果査読

26 被引用数 (Scopus)

抄録

A new synthetic approach to the bicyclo[3.3.1]nonane system, a common structure in a number of polyisoprenylated phloroglucinol derivatives (phloroglucins), has been developed. The key step in our approach is a 'one-pot' procedure of two successive reactions, the intramolecular cyclopropanation reaction which affords the tricyclo[4.4.0.05,7]dec-2-ene derivative and its methoxy group directed regioselective ring-opening reaction mediated by ZnCl2, producing the desired bicyclo[3.3.1]nonane as the sole product.

本文言語English
ページ(範囲)4873-4877
ページ数5
ジャーナルTetrahedron Letters
48
28
DOI
出版ステータスPublished - 2007 7 9

ASJC Scopus subject areas

  • 生化学
  • 創薬
  • 有機化学

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