Synthetic studies on (-)-scabronine A

Hideaki Watanabe, Masahisa Nakada

研究成果: Article査読

18 被引用数 (Scopus)

抄録

This Letter describes synthetic studies on (-)-scabronine A utilizing a new chiral building block successfully prepared via the catalytic asymmetric intramolecular cyclopropanation (IMCP) of an α-diazo-β-keto sulfone. The crucial transformations in this study are the coupling reaction of two fragments between the positions adjacent to a quaternary carbon center, the intramolecular aldol reaction, the C14 hydroxyl-directed hydrogenation, and the ring-expansion reaction to furnish the 5-6-7 tricyclic cyathane skeleton.

本文言語English
ページ(範囲)1518-1522
ページ数5
ジャーナルTetrahedron Letters
49
9
DOI
出版ステータスPublished - 2008 2 25

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

フィンガープリント 「Synthetic studies on (-)-scabronine A」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル