Synthetic studies on the taxane skeleton: effective construction of eight-membered carbocyclic ring by palladium-catalyzed intramolecular α-alkenylation of a methyl ketone

Masayuki Utsugi, Yasuaki Kamada, Masahisa Nakada*

*この研究の対応する著者

研究成果: Article査読

11 被引用数 (Scopus)

抄録

A new method for the construction of the eight-membered carbocyclic ring in the taxane skeleton is described. The palladium-catalyzed intramolecular α-alkenylation of a methyl ketone effectively constructed the eight-membered carbocyclic ring in the taxol model compound. To the best of our knowledge, this reaction is the first example of forming an eight-membered carbocyclic ring by the palladium-catalyzed intramolecular α-alkenylation of a ketone.

本文言語English
ページ(範囲)4754-4757
ページ数4
ジャーナルTetrahedron Letters
49
32
DOI
出版ステータスPublished - 2008 8 4

ASJC Scopus subject areas

  • 生化学
  • 創薬
  • 有機化学

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