Synthetic study on an antitumor antibiotic rhizoxin by using an enzymatic process on prochiral B-substituted glutarates

Susumu Kobayashi, Masahisa Nakada, Masaji Ohno

研究成果: Article査読

6 被引用数 (Scopus)

抄録

Enantio- and stereoselective synthesis of the right-half segment (1, C1-C9) of macrolide antibiotic rhizoxin was achieved by enzymatic approach. Characteristic features of the present synthesis are (1) enantioselective hydrolysis of prochiral p-substituted glutarates with pig liver esterase, and (2) stereoselective cyclichydroboration of the 1,5-diene 8.

本文言語English
ページ(範囲)1121-1124
ページ数4
ジャーナルPure and Applied Chemistry
64
8
DOI
出版ステータスPublished - 1992 1 1
外部発表はい

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)

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