@article{fbbe3c869b764333b034470e55a0129e,
title = "Systemic Analysis of Atg5-Null Mice Rescued from Neonatal Lethality by Transgenic ATG5 Expression in Neurons",
abstract = "Autophagy is a cytoplasmic degradation system that is important for starvation adaptation and cellular quality control. Previously, we reported that Atg5-null mice are neonatal lethal; however, the exact cause of their death remains unknown. Here, we show that restoration of ATG5 in the brain is sufficient to rescue Atg5-null mice from neonatal lethality. This suggests that neuronal dysfunction, including suckling failure, is the primary cause of the death of Atg5-null neonates, which would further be accelerated by nutrient insufficiency due to a systemic failure in autophagy. The rescued Atg5-null mouse model, as a resource, allows us to investigate the physiological roles of autophagy in the whole body after the neonatal period. These rescued mice demonstrate previously unappreciated abnormalities such as hypogonadism and iron-deficiency anemia. These observations provide new insights into the physiological roles of the autophagy factor ATG5.",
keywords = "Atg5, anemia, autophagy, hormone, hypogonadism, iron deficiency, neonate",
author = "Yoshii, {Saori R.} and Akiko Kuma and Takumi Akashi and Taichi Hara and Atsushi Yamamoto and Yoshitaka Kurikawa and Eisuke Itakura and Satoshi Tsukamoto and Hiroshi Shitara and Yoshinobu Eishi and Noboru Mizushima",
note = "Funding Information: We thank Dr. Kenji Sakimura for the NSE promoter and Keiko Igarashi for technical assistance in histological studies. We thank Ms. Yuka Hiraoka and Drs. Yoshiki Miura and Takashi Ueno of the Laboratory of Proteomics and BioMolecular Science at Juntendo University Graduate School of Medicine for amino acid analysis. This work was supported by JST PRESTO (to A.K.), a Grant-in-Aid for JSPS Fellows (grant number 25 ∗ 7082 ) (to S.R.Y), Funding Program for Next Generation World-Leading Researchers ( LS043 ), and a JSPS KAKENHI Grant-in-Aid for Scientific Research on Innovative Areas (grant number 25111005 ) (to N.M.). Publisher Copyright: {\textcopyright} 2016 Elsevier Inc.",
year = "2016",
month = oct,
day = "10",
doi = "10.1016/j.devcel.2016.09.001",
language = "English",
volume = "39",
pages = "116--130",
journal = "Developmental Cell",
issn = "1534-5807",
publisher = "Cell Press",
number = "1",
}