Tailoring the properties of guanosine-based supramolecular hydrogels

Lauren E. Buerkle, Zheng Li, Alexander M. Jamieson, Stuart J. Rowan

研究成果: Article査読

72 被引用数 (Scopus)

抄録

We demonstrate that very stable hydrogels can be formed in aqueous potassium chloride solution by mixing a well-known gelator (guanosine, G) with a nongelator of similar structure (2′, 3′, 5′-tri-O- acetylguanosine, TAcG), and through a variety of characterization methods including rheology, small-angle neutron scattering, differential scanning calorimetry, and atomic force microscopy, we report substantial progress toward elucidating the factors that control the structure and stability of this fibrous gel system. The results suggest that the tailorability, long lifetime stability, and thermo-mechanical behavior of these gels derives from a reduction in the driving force toward crystallization with increased hydrophobic (TAcG) content, accompanied by a simultaneous decrease in fiber length and an increase in fiber width.

本文言語English
ページ(範囲)8833-8840
ページ数8
ジャーナルLangmuir
25
15
DOI
出版ステータスPublished - 2009 8月 4
外部発表はい

ASJC Scopus subject areas

  • 電気化学
  • 凝縮系物理学
  • 表面および界面
  • 材料科学(全般)
  • 分光学

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