Template-dependent peptide formation on ribosomes catalyzed by pyridine

Itaru Nitta, Takuya Ueda, Kimitsuna Watanabe

研究成果: Article査読

11 被引用数 (Scopus)

抄録

We found that poly(U)-dependent polyphenylalanine synthesis on Escherichia coli ribosomes was extremely accelerated in the presence of a high concentration of pyridine. In this reaction, chemical energy sources, such as ATP and GTP, and soluble protein factors are not required, but the template and ribosomes are essential for the progress of the reaction. The reaction was inhibited by the antibiotics which inhibit the usual bacterial translation process on the ribosomes. These observations clearly demonstrate that the pyridine-catalyzed amino acid condensation reaction proceeds on the ribosome.

本文言語English
ページ(範囲)803-807
ページ数5
ジャーナルJournal of biochemistry
115
4
DOI
出版ステータスPublished - 1994 4
外部発表はい

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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