The activity of isolated neurons and the modulatory state of an isolated nervous system represent a recent behavioural state

Varvara E. Dyakonova, Laszlo Hernadi, Etsuro Ito, Taisia L. Dyakonova, Ilya A. Chistopolsky, Igor S. Zakharov, Dmitri A. Sakharov

研究成果: Article

11 被引用数 (Scopus)

抄録

Behavioural/motivational state is known to influence nearly all aspects of physiology and behaviour. The cellular basis of behavioural state control is only partially understood.Our investigation, performed on the pond snail Lymnaea stagnalis whose nervous systemis useful for work on completely isolated neurons, provided several results related to this problem. First,we demonstrated that the behavioural state can produce long-term changes in individual neurons that persist even after neuron isolation from the nervous system. Specifically, we found that pedal serotonergic neurons that control locomotion show higher activity and lower membrane potential after being isolated from the nervous systems of hungry animals. Second, we showed that the modulatory state (the chemical neuroactive microenvironment of the central ganglia) changes in accordance with the nutritional state of an animal and produces predicted changes in single isolated locomotor neurons. Third,we report that observedhunger-inducedeffects canbeexplained by the increased synthesis of serotonin in pedal serotonergic neurons, which has an impact on the electrical activity of isolated serotonergic neurons and the intensity of extrasynaptic serotonin release from the pedal ganglia.

元の言語English
ページ(範囲)1151-1158
ページ数8
ジャーナルJournal of Experimental Biology
218
発行部数8
DOI
出版物ステータスPublished - 2015 4 15

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Physiology
  • Aquatic Science
  • Animal Science and Zoology
  • Molecular Biology
  • Insect Science

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