The association between homocysteine, arterial stiffness and executive function middle-age and older women

Ai Shindo-Hamasaki, Nobuhiko Akazawa, Reiko Momma, Seiji Maeda*

*この研究の対応する著者

研究成果: Article査読

抄録

Age-related decreases in executive function and an increase in arterial stiffness and plasma homocysteine levels are related to the risk of dementia. However, the association between executive function, arterial stiffness, and homocysteine levels remains unclear. This study aimed to investigate the relationship between executive function, arterial stiffness, and plasma homocysteine in 82 middle-aged and older women. The Stroop interference time, Brachial-ankle Pulse Wave Velocity (baPWV), and plasma homocysteine concentration were collected. The correlation analyses revealed that the Stroop interference time was significantly correlated with plasma homocysteine (r = 0.40, p < 0.001) and baPWV (r = 0.38, p = 0.001). In addition, plasma homocysteine levels were significantly correlated with baPWV (r = 0.48, p < 0.001). In the mediated analyses, the plasma homocysteine level directly (b = 0.24; p = 0.037) and indirectly (b = 0.12, 95% confidence interval [0.007, 0.238]) affected the Stroop interference time. These results suggest that higher plasma homocysteine levels are associated with a decline in executive function mediated by higher artery stiffness in middle-aged and older women.

本文言語English
ページ(範囲)32-37
ページ数6
ジャーナルArtery Research
27
1
DOI
出版ステータスPublished - 2021 3
外部発表はい

ASJC Scopus subject areas

  • 解剖学
  • 循環器および心血管医学
  • 生理学(医学)

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