The association between vitamin d and zinc status and the progression of clinical symptoms among outpatients infected with sars-cov-2 and potentially non-infected participants: A cross-sectional study

Sahar Golabi, Maryam Adelipour, Sara Mobarak, Maghsud Piri, Maryam Seyedtabib, Reza Bagheri, Katsuhiko Suzuki, Damoon Ashtary-Larky, Fatemeh Maghsoudi, Mahshid Naghashpour*

*この研究の対応する著者

研究成果: Article査読

4 被引用数 (Scopus)

抄録

Vitamin D and zinc are important components of nutritional immunity. This study compared the serum concentrations of 25-hydroxyvitamin D (25(OH)D) and zinc in COVID-19 outpatients with those of potentially non-infected participants. The association of clinical symptoms with vitamin D and zinc status was also examined. A checklist and laboratory examination were applied to collect data in a cross-sectional study conducted on 53 infected outpatients with COVID-19 and 53 potentially non-infected participants. Serum concentration of 25(OH)D were not significantly lower in patients with moderate illness (19 ± 12 ng/mL) than patients with asymptomatic or mild illness (29 ± 18 ng/mL), with a trend noted for a lower serum concentration of 25(OH)D in moderate than asymptomatic or mild illness patients (p = 0.054). Infected patients (101 ± 18 µg/dL) showed a lower serum concentration of zinc than potentially non-infected participants (114 ± 13 µg/dL) (p = 0.01). Patients with normal (odds ratio (OR), 0.19; p ≤ 0.001) and insufficient (OR, 0.3; p = 0.007) vitamin D status at the second to seventh days of disease had decreased OR of general symptoms compared to patients with vitamin D deficiency. This study revealed the importance of 25(OH)D measurement to predict the progression of general and pulmonary symptoms and showed that infected patients had significantly lower zinc concentrations than potentially non-infected partici-pants.

本文言語English
論文番号3368
ジャーナルNutrients
13
10
DOI
出版ステータスPublished - 2021 10月

ASJC Scopus subject areas

  • 食品科学
  • 栄養および糖尿病

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