The complete genomic sequence of Niocardia farcinica IFM 10152

Jun Ishikawa, Atsushi Yamashita, Yuzuru Mikami, Yasutaka Hoshino, Haruyo Kurita, Kunimoto Hotta, Tadayoshi Shiba, Masahira Hattori

研究成果: Article査読

222 被引用数 (Scopus)

抄録

We determined the genomic sequence of Nocardia farcinica IFM 10152, a clinical isolate, and revealed the molecular basis of its versatility. The genome consists of a single circular chromosome of 6,021,225 bp with an average G+C content of 70.8% and two plasmids of 184,027 (pNFl) and 87,093 (pNF2) bp with average G+C contents of 67.2% and 68.4%, respectively. The chromosome encoded 5,674 putative protein-coding sequences, including many candidate genes for virulence and multidrug resistance as well as secondary metabolism. Analyses of paralogous protein families suggest that gene duplications have resulted in a bacterium that can survive not only in soil environments but also in animal tissues, resulting in disease.

本文言語English
ページ(範囲)14925-14930
ページ数6
ジャーナルProceedings of the National Academy of Sciences of the United States of America
101
41
DOI
出版ステータスPublished - 2004 10 12
外部発表はい

ASJC Scopus subject areas

  • 遺伝学
  • 一般

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