The development and evolution of left-right asymmetry in invertebrates: Lessons from Drosophila and snails

Takashi Okumura, Hiroki Utsuno, Junpei Kuroda, Edmund Gittenberger, Takahiro Asami*, Kenji Matsuno

*この研究の対応する著者

研究成果: Article査読

55 被引用数 (Scopus)

抄録

The unique nature of body handedness, which is distinct from the anteroposterior and dorsoventral polarities, has been attracting growing interest in diverse biological disciplines. Recent research progress on the left-right asymmetry of animal development has focused new attention on the mechanisms underlying the development and evolution of invertebrate handedness. This exploratory review of currently available information illuminates the prospective value of Drosophila and pulmonate snails for innovative new research aimed at elucidating these mechanisms. For example, findings in Drosophila and snails suggest that an actin filament-dependent mechanism may be evolutionarily conserved in protostomes. The polarity conservation of primary asymmetry across most metazoan phyla, which visceral handedness represents, indicates developmental constraint and purifying selection as possible but unexplored mechanisms. Comparative studies using Drosophila and snails, which have the great advantages of using genetic and evolutionary approaches, will accelerate our understanding of the mechanisms governing the conservation and diversity of animal handedness.

本文言語English
ページ(範囲)3497-3515
ページ数19
ジャーナルDevelopmental Dynamics
237
12
DOI
出版ステータスPublished - 2008 12
外部発表はい

ASJC Scopus subject areas

  • 発生生物学

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