The effects of moderate-, strenuous- and over-training on oxidative stress markers, DNA repair, and memory, in rat brain

Helga Ogonovszky, István Berkes, Shuzo Kumagai, Takao Kaneko, Shoichi Tahara, Sataro Goto, Zsolt Radák*

*この研究の対応する著者

研究成果: Article査読

132 被引用数 (Scopus)

抄録

We have tested the hypothesis that training with moderate- (MT), strenuous- (ST), or over- (OT) load can cause alterations in memory, lipid peroxidation, protein oxidation, DNA damage, activity of 8-oxoG-DNA glycosylase (OGG1) and brain-derived neurotrophic factor (BDNF), in rat brain. Rat memory was assessed by a passive avoidance test and the ST and OT group demonstrated improved memory. The content of BDNF was increased only in the OT group. The oxidative damage of lipids and DNA, as measured by thiobarbituric acid reactive substances (TBARS), and 8-hydroxydeoxyguanosine (8-OHdG), did not change significantly with exercise. Similarly, the activity of DNA repair enzyme, 8-oxoguanine DNA glycosylase (OGG1), was not altered with exercise training. On the other hand, the content of reactive carbonyl derivatives (RCDs) decreased in all groups and the decrease reached significance levels in the ST and OT groups. The activity of the proteasome complex increased in the brain of OT. The findings of this study imply that over-training does not induce oxidative stress in the brain and does not cause loss of memory. The improved memory was associated with enhanced BDNF content.

本文言語English
ページ(範囲)635-640
ページ数6
ジャーナルNeurochemistry International
46
8
DOI
出版ステータスPublished - 2005 6
外部発表はい

ASJC Scopus subject areas

  • 細胞および分子神経科学
  • 細胞生物学

フィンガープリント

「The effects of moderate-, strenuous- and over-training on oxidative stress markers, DNA repair, and memory, in rat brain」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル