The Enzyme Cyp26b1 mediates inhibition of mast cell activation by fibroblasts to maintain skin-barrier homeostasis

Yosuke Kurashima, Takeaki Amiya, Kumiko Fujisawa, Naoko Shibata, Yuji Suzuki, Yuta Kogure, Eri Hashimoto, Atsushi Otsuka, Kenji Kabashima, Shintaro Sato, Takeshi Sato, Masato Kubo, Shizuo Akira, Kensuke Miyake, Jun Kunisawa*, Hiroshi Kiyono

*この研究の対応する著者

研究成果: Article査読

58 被引用数 (Scopus)

抄録

Mast cells (MCs) mature locally, thus possessing tissue-dependent phenotypes for their critical roles in both protective immunity against pathogens and the development of allergy or inflammation. We previously reported that MCs highly express P2X7, a receptor for extracellular ATP, in the colon but not in the skin. The ATP-P2X7 pathway induces MC activation and consequently exacerbates the inflammation. Here, we identified the mechanisms by which P2X7 expression on MCs is reduced by fibroblasts in the skin, but not in the other tissues. The retinoic-acid-degrading enzyme Cyp26b1 is highly expressed in skin fibroblasts, and its inhibition resulted in the upregulation of P2X7 on MCs. We also noted the increased expression of P2X7 on skin MCs and consequent P2X7- and MC-dependent dermatitis (so-called retinoid dermatitis) in the presence of excessive amounts of retinoic acid. These results demonstrate a unique skin-barrier homeostatic network operating through Cyp26b1-mediated inhibition of ATP-dependent MC activation by fibroblasts.

本文言語English
ページ(範囲)530-541
ページ数12
ジャーナルImmunity
40
4
DOI
出版ステータスPublished - 2014 4月 17
外部発表はい

ASJC Scopus subject areas

  • 免疫アレルギー学
  • 免疫学
  • 感染症

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