The first total synthesis and structural determination of (+)-BE-52440A

Kuniaki Tatsuta, Yoshikazu Suzuki, Tatsuya Toriumi, Yoshiaki Furuya, Seijiro Hosokawa

    研究成果: Article

    18 引用 (Scopus)

    抄録

    The first total synthesis and structural determination of (+)-BE-52440A have been achieved by enantiodivergent synthesis. S-Bridging dimerization including SN2 epoxy-opening reaction of tetrasubstituted epoxide 2 with sodium sulfide has been achieved in excellent yield with high regioselectivity. The structure of (+)-BE-52440A was determined to be the dimer of kalafungin type pyranonaphthoquinone.

    元の言語English
    ページ（範囲）8018-8021
    ページ数4
    ジャーナルTetrahedron Letters
    巻48
    発行部数45
    DOI
    出版物ステータスPublished - 2007 11 5

    Fingerprint

    Regioselectivity
    Dimerization
    Epoxy Compounds
    Dimers
    BE 52440 A
    sodium sulfide
    kalafungin

    ASJC Scopus subject areas

    • Biochemistry
    • Organic Chemistry
    • Drug Discovery

    これを引用

    The first total synthesis and structural determination of (+)-BE-52440A. / Tatsuta, Kuniaki; Suzuki, Yoshikazu; Toriumi, Tatsuya; Furuya, Yoshiaki; Hosokawa, Seijiro.

    ：: Tetrahedron Letters, 巻 48, 番号 45, 05.11.2007, p. 8018-8021.

    研究成果: Article

    Tatsuta, K, Suzuki, Y, Toriumi, T, Furuya, Y & Hosokawa, S 2007, 'The first total synthesis and structural determination of (+)-BE-52440A', Tetrahedron Letters, 巻. 48, 番号 45, pp. 8018-8021. https://doi.org/10.1016/j.tetlet.2007.09.039
    Tatsuta K, Suzuki Y, Toriumi T, Furuya Y, Hosokawa S. The first total synthesis and structural determination of (+)-BE-52440A. Tetrahedron Letters. 2007 11 5;48(45):8018-8021. https://doi.org/10.1016/j.tetlet.2007.09.039
    Tatsuta, Kuniaki ; Suzuki, Yoshikazu ; Toriumi, Tatsuya ; Furuya, Yoshiaki ; Hosokawa, Seijiro. / The first total synthesis and structural determination of (+)-BE-52440A. ：: Tetrahedron Letters. 2007 ; 巻 48, 番号 45. pp. 8018-8021.
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    AU - Tatsuta, Kuniaki

    AU - Suzuki, Yoshikazu

    AU - Toriumi, Tatsuya

    AU - Furuya, Yoshiaki

    AU - Hosokawa, Seijiro

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    KW - Enantiodivergent synthesis

    KW - Tetrasubstituted epoxide

    KW - Total synthesis

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