The first total synthesis and structural determination of (+)-BE-52440A

Kuniaki Tatsuta; Yoshikazu Suzuki; Tatsuya Toriumi; Yoshiaki Furuya; Seijiro Hosokawa

doi:10.1016/j.tetlet.2007.09.039

The first total synthesis and structural determination of (+)-BE-52440A

Kuniaki Tatsuta, Yoshikazu Suzuki, Tatsuya Toriumi, Yoshiaki Furuya, Seijiro Hosokawa

先進理工学部

研究成果: Article

19 引用（Scopus）

抜粋

The first total synthesis and structural determination of (+)-BE-52440A have been achieved by enantiodivergent synthesis. S-Bridging dimerization including S_N2 epoxy-opening reaction of tetrasubstituted epoxide 2 with sodium sulfide has been achieved in excellent yield with high regioselectivity. The structure of (+)-BE-52440A was determined to be the dimer of kalafungin type pyranonaphthoquinone.

元の言語	English
ページ（範囲）	8018-8021
ページ数	4
ジャーナル	Tetrahedron Letters
巻	48
発行部数	45
DOI	https://doi.org/10.1016/j.tetlet.2007.09.039
出版物ステータス	Published - 2007 11 5

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

文献にアクセス

10.1016/j.tetlet.2007.09.039

フィンガープリント The first total synthesis and structural determination of (+)-BE-52440A' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

これを引用

Tatsuta, K., Suzuki, Y., Toriumi, T., Furuya, Y., & Hosokawa, S. (2007). The first total synthesis and structural determination of (+)-BE-52440A. Tetrahedron Letters, 48(45), 8018-8021. https://doi.org/10.1016/j.tetlet.2007.09.039

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abstract = "The first total synthesis and structural determination of (+)-BE-52440A have been achieved by enantiodivergent synthesis. S-Bridging dimerization including SN2 epoxy-opening reaction of tetrasubstituted epoxide 2 with sodium sulfide has been achieved in excellent yield with high regioselectivity. The structure of (+)-BE-52440A was determined to be the dimer of kalafungin type pyranonaphthoquinone.",

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author = "Kuniaki Tatsuta and Yoshikazu Suzuki and Tatsuya Toriumi and Yoshiaki Furuya and Seijiro Hosokawa",

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T1 - The first total synthesis and structural determination of (+)-BE-52440A

AU - Tatsuta, Kuniaki

AU - Suzuki, Yoshikazu

AU - Toriumi, Tatsuya

AU - Furuya, Yoshiaki

AU - Hosokawa, Seijiro

PY - 2007/11/5

Y1 - 2007/11/5

N2 - The first total synthesis and structural determination of (+)-BE-52440A have been achieved by enantiodivergent synthesis. S-Bridging dimerization including SN2 epoxy-opening reaction of tetrasubstituted epoxide 2 with sodium sulfide has been achieved in excellent yield with high regioselectivity. The structure of (+)-BE-52440A was determined to be the dimer of kalafungin type pyranonaphthoquinone.

AB - The first total synthesis and structural determination of (+)-BE-52440A have been achieved by enantiodivergent synthesis. S-Bridging dimerization including SN2 epoxy-opening reaction of tetrasubstituted epoxide 2 with sodium sulfide has been achieved in excellent yield with high regioselectivity. The structure of (+)-BE-52440A was determined to be the dimer of kalafungin type pyranonaphthoquinone.

KW - BE-52440A

KW - Dimerization

KW - Enantiodivergent synthesis

KW - Tetrasubstituted epoxide

KW - Total synthesis

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