@article{8a851323e0084c708e5cbab0ea13dc5b,
title = "The first total synthesis and structural determination of TMC-66",
abstract = "The first total synthesis and structural determination of TMC-66, an ECE inhibitor, was achieved in short steps by efficient construction and coupling of segments. The oxidative coupling with phenols attaching to electron-withdrawing groups was realized with a novel copper(II) reagent.",
keywords = "ECE inhibitor, Oxidative coupling, Structural determination, TMC-66, Total synthesis",
author = "Seijiro Hosokawa and Hitoshi Fumiyama and Hisato Fukuda and Tomohiro Fukuda and Masashi Seki and Kuniaki Tatsuta",
note = "Funding Information: This work was financially supported by the 21COE program {\textquoteleft}Center for Practical Nano-Chemistry{\textquoteright}, the Consolidated Research Institute for Advanced Science and Medical Care, the Global COE program {\textquoteleft}Center for Practical Chemical Wisdom{\textquoteright}, and Scientific Research on Priority Area {\textquoteleft}Creation of Biologically Functional Molecules{\textquoteright} from the Ministry of Education, Culture, Sports, Science and Technology. ",
year = "2007",
month = oct,
day = "8",
doi = "10.1016/j.tetlet.2007.08.037",
language = "English",
volume = "48",
pages = "7305--7308",
journal = "Tetrahedron Letters",
issn = "0040-4039",
publisher = "Elsevier Limited",
number = "41",
}