The first total synthesis and structural determination of TMC-66

Seijiro Hosokawa, Hitoshi Fumiyama, Hisato Fukuda, Tomohiro Fukuda, Masashi Seki, Kuniaki Tatsuta

    研究成果: Article

    19 引用 (Scopus)

    抄録

    The first total synthesis and structural determination of TMC-66, an ECE inhibitor, was achieved in short steps by efficient construction and coupling of segments. The oxidative coupling with phenols attaching to electron-withdrawing groups was realized with a novel copper(II) reagent.

    元の言語English
    ページ（範囲）7305-7308
    ページ数4
    ジャーナルTetrahedron Letters
    巻48
    発行部数41
    DOI
    出版物ステータスPublished - 2007 10 8

    Fingerprint

    Oxidative Coupling
    Phenols
    Copper
    Electrons
    TMC 66

    ASJC Scopus subject areas

    • Biochemistry
    • Organic Chemistry
    • Drug Discovery

    これを引用

    Hosokawa, S., Fumiyama, H., Fukuda, H., Fukuda, T., Seki, M., & Tatsuta, K. (2007). The first total synthesis and structural determination of TMC-66. Tetrahedron Letters, 48(41), 7305-7308. https://doi.org/10.1016/j.tetlet.2007.08.037

    The first total synthesis and structural determination of TMC-66. / Hosokawa, Seijiro; Fumiyama, Hitoshi; Fukuda, Hisato; Fukuda, Tomohiro; Seki, Masashi; Tatsuta, Kuniaki.

    ：: Tetrahedron Letters, 巻 48, 番号 41, 08.10.2007, p. 7305-7308.

    研究成果: Article

    Hosokawa, S, Fumiyama, H, Fukuda, H, Fukuda, T, Seki, M & Tatsuta, K 2007, 'The first total synthesis and structural determination of TMC-66', Tetrahedron Letters, 巻. 48, 番号 41, pp. 7305-7308. https://doi.org/10.1016/j.tetlet.2007.08.037
    Hosokawa S, Fumiyama H, Fukuda H, Fukuda T, Seki M, Tatsuta K. The first total synthesis and structural determination of TMC-66. Tetrahedron Letters. 2007 10 8;48(41):7305-7308. https://doi.org/10.1016/j.tetlet.2007.08.037
    Hosokawa, Seijiro ; Fumiyama, Hitoshi ; Fukuda, Hisato ; Fukuda, Tomohiro ; Seki, Masashi ; Tatsuta, Kuniaki. / The first total synthesis and structural determination of TMC-66. ：: Tetrahedron Letters. 2007 ; 巻 48, 番号 41. pp. 7305-7308.
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    AU - Seki, Masashi

    AU - Tatsuta, Kuniaki

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    KW - Structural determination

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