The first total synthesis and structural determination of TMC-66

Seijiro Hosokawa; Hitoshi Fumiyama; Hisato Fukuda; Tomohiro Fukuda; Masashi Seki; Kuniaki Tatsuta

doi:10.1016/j.tetlet.2007.08.037

The first total synthesis and structural determination of TMC-66

Seijiro Hosokawa, Hitoshi Fumiyama, Hisato Fukuda, Tomohiro Fukuda, Masashi Seki, Kuniaki Tatsuta

先進理工学部

研究成果: Article › 査読

21 被引用数 (Scopus)

抄録

The first total synthesis and structural determination of TMC-66, an ECE inhibitor, was achieved in short steps by efficient construction and coupling of segments. The oxidative coupling with phenols attaching to electron-withdrawing groups was realized with a novel copper(II) reagent.

本文言語	English
ページ（範囲）	7305-7308
ページ数	4
ジャーナル	Tetrahedron Letters
巻	48
号	41
DOI	https://doi.org/10.1016/j.tetlet.2007.08.037
出版ステータス	Published - 2007 10 8

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

文献へのアクセス

10.1016/j.tetlet.2007.08.037

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引用スタイル

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abstract = "The first total synthesis and structural determination of TMC-66, an ECE inhibitor, was achieved in short steps by efficient construction and coupling of segments. The oxidative coupling with phenols attaching to electron-withdrawing groups was realized with a novel copper(II) reagent.",

keywords = "ECE inhibitor, Oxidative coupling, Structural determination, TMC-66, Total synthesis",

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AU - Fukuda, Hisato

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AU - Seki, Masashi

AU - Tatsuta, Kuniaki

PY - 2007/10/8

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KW - Oxidative coupling

KW - Structural determination

KW - TMC-66

KW - Total synthesis

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