The first total synthesis and structural determination of TMC-66

Seijiro Hosokawa, Hitoshi Fumiyama, Hisato Fukuda, Tomohiro Fukuda, Masashi Seki, Kuniaki Tatsuta

    研究成果: Article

    19 引用 (Scopus)

    抄録

    The first total synthesis and structural determination of TMC-66, an ECE inhibitor, was achieved in short steps by efficient construction and coupling of segments. The oxidative coupling with phenols attaching to electron-withdrawing groups was realized with a novel copper(II) reagent.

    元の言語English
    ページ(範囲)7305-7308
    ページ数4
    ジャーナルTetrahedron Letters
    48
    発行部数41
    DOI
    出版物ステータスPublished - 2007 10 8

    Fingerprint

    Oxidative Coupling
    Phenols
    Copper
    Electrons
    TMC 66

    ASJC Scopus subject areas

    • Biochemistry
    • Organic Chemistry
    • Drug Discovery

    これを引用

    Hosokawa, S., Fumiyama, H., Fukuda, H., Fukuda, T., Seki, M., & Tatsuta, K. (2007). The first total synthesis and structural determination of TMC-66. Tetrahedron Letters, 48(41), 7305-7308. https://doi.org/10.1016/j.tetlet.2007.08.037

    The first total synthesis and structural determination of TMC-66. / Hosokawa, Seijiro; Fumiyama, Hitoshi; Fukuda, Hisato; Fukuda, Tomohiro; Seki, Masashi; Tatsuta, Kuniaki.

    :: Tetrahedron Letters, 巻 48, 番号 41, 08.10.2007, p. 7305-7308.

    研究成果: Article

    Hosokawa, S, Fumiyama, H, Fukuda, H, Fukuda, T, Seki, M & Tatsuta, K 2007, 'The first total synthesis and structural determination of TMC-66', Tetrahedron Letters, 巻. 48, 番号 41, pp. 7305-7308. https://doi.org/10.1016/j.tetlet.2007.08.037
    Hosokawa, Seijiro ; Fumiyama, Hitoshi ; Fukuda, Hisato ; Fukuda, Tomohiro ; Seki, Masashi ; Tatsuta, Kuniaki. / The first total synthesis and structural determination of TMC-66. :: Tetrahedron Letters. 2007 ; 巻 48, 番号 41. pp. 7305-7308.
    @article{8a851323e0084c708e5cbab0ea13dc5b,
    title = "The first total synthesis and structural determination of TMC-66",
    abstract = "The first total synthesis and structural determination of TMC-66, an ECE inhibitor, was achieved in short steps by efficient construction and coupling of segments. The oxidative coupling with phenols attaching to electron-withdrawing groups was realized with a novel copper(II) reagent.",
    keywords = "ECE inhibitor, Oxidative coupling, Structural determination, TMC-66, Total synthesis",
    author = "Seijiro Hosokawa and Hitoshi Fumiyama and Hisato Fukuda and Tomohiro Fukuda and Masashi Seki and Kuniaki Tatsuta",
    year = "2007",
    month = "10",
    day = "8",
    doi = "10.1016/j.tetlet.2007.08.037",
    language = "English",
    volume = "48",
    pages = "7305--7308",
    journal = "Tetrahedron Letters",
    issn = "0040-4039",
    publisher = "Elsevier Limited",
    number = "41",

    }

    TY - JOUR

    T1 - The first total synthesis and structural determination of TMC-66

    AU - Hosokawa, Seijiro

    AU - Fumiyama, Hitoshi

    AU - Fukuda, Hisato

    AU - Fukuda, Tomohiro

    AU - Seki, Masashi

    AU - Tatsuta, Kuniaki

    PY - 2007/10/8

    Y1 - 2007/10/8

    N2 - The first total synthesis and structural determination of TMC-66, an ECE inhibitor, was achieved in short steps by efficient construction and coupling of segments. The oxidative coupling with phenols attaching to electron-withdrawing groups was realized with a novel copper(II) reagent.

    AB - The first total synthesis and structural determination of TMC-66, an ECE inhibitor, was achieved in short steps by efficient construction and coupling of segments. The oxidative coupling with phenols attaching to electron-withdrawing groups was realized with a novel copper(II) reagent.

    KW - ECE inhibitor

    KW - Oxidative coupling

    KW - Structural determination

    KW - TMC-66

    KW - Total synthesis

    UR - http://www.scopus.com/inward/record.url?scp=34548508177&partnerID=8YFLogxK

    UR - http://www.scopus.com/inward/citedby.url?scp=34548508177&partnerID=8YFLogxK

    U2 - 10.1016/j.tetlet.2007.08.037

    DO - 10.1016/j.tetlet.2007.08.037

    M3 - Article

    VL - 48

    SP - 7305

    EP - 7308

    JO - Tetrahedron Letters

    JF - Tetrahedron Letters

    SN - 0040-4039

    IS - 41

    ER -