The first total synthesis and structural determination of YCM1008A

Kuniaki Tatsuta, Takahiro Yamaguchi, Yusuke Tsuda, Yumiko Yamaguchi, Nobutaka Hattori, Hiroshi Nagai, Seijiro Hosokawa

研究成果: Article

16 引用 (Scopus)

抜粋

The first total synthesis and structural determination of YCM1008A, a Ca2+ signaling inhibitor, have been achieved. The N-methoxy pyrano-pyridone moiety was synthesized by successive O- and N-conjugate additions with diketoamide 15. The absolute structure was determined to be (2R,3R,4S,8′R)-configuration.

元の言語English
ページ(範囲)4187-4190
ページ数4
ジャーナルTetrahedron Letters
48
発行部数24
DOI
出版物ステータスPublished - 2007 6 11

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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  • これを引用

    Tatsuta, K., Yamaguchi, T., Tsuda, Y., Yamaguchi, Y., Hattori, N., Nagai, H., & Hosokawa, S. (2007). The first total synthesis and structural determination of YCM1008A. Tetrahedron Letters, 48(24), 4187-4190. https://doi.org/10.1016/j.tetlet.2007.04.074