抄録
The first total synthesis of hibarimicinone has been achieved. The polyhydroxydecalin moieties (AB and GH rings) have been synthesized from sulfonylenone 4 derived from d-arabinose. The chiral biaryl 20 was coupled with two polyhydroxydecalins 11 by Michael-Dieckmann type condensation to give the eight rings system. Aromatization and oxidation with Ag + gave quinone 24, and the subsequential transannular etheration gave the hibarimicinone skeleton. Deprotection and tautomerization were performed in one pot to give hibarimicinone (1).
本文言語 | English |
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ページ(範囲) | 422-425 |
ページ数 | 4 |
ジャーナル | Tetrahedron Letters |
巻 | 53 |
号 | 4 |
DOI | |
出版ステータス | Published - 2012 1 25 |
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry