@article{f3f7c88f6ae94c59a2663ea9b46eb6f6,
title = "The first total synthesis of hibarimicinone, a potent v-Src tyrosine kinase inhibitor",
abstract = "The first total synthesis of hibarimicinone has been achieved. The polyhydroxydecalin moieties (AB and GH rings) have been synthesized from sulfonylenone 4 derived from d-arabinose. The chiral biaryl 20 was coupled with two polyhydroxydecalins 11 by Michael-Dieckmann type condensation to give the eight rings system. Aromatization and oxidation with Ag + gave quinone 24, and the subsequential transannular etheration gave the hibarimicinone skeleton. Deprotection and tautomerization were performed in one pot to give hibarimicinone (1).",
keywords = "Hauser annulation, Hibarimicin, Hibarimicinone, Thiolactone, Total synthesis",
author = "Kuniaki Tatsuta and Tomohiro Fukuda and Tatsuya Ishimori and Rearu Yachi and Shinpei Yoshida and Hiroshi Hashimoto and Seijiro Hosokawa",
note = "Funding Information: Authors thank Professor Hiroshi Hori in Tamagawa University, Professor Yasuhiro Igarashi and Professor Tamotsu Furumai in Toyama Prefectural University for providing hibarimicinone and its NMR spectra. Authors are grateful for the financial support to GCOE program {\textquoteleft}Center for Practical Chemical Wisdom{\textquoteright}, and The Ministry of Education, Culture, Sports, Science and Technology (MEXT). ",
year = "2012",
month = jan,
day = "25",
doi = "10.1016/j.tetlet.2011.11.062",
language = "English",
volume = "53",
pages = "422--425",
journal = "Tetrahedron Letters",
issn = "0040-4039",
publisher = "Elsevier Limited",
number = "4",
}