抜粋
The first total synthesis of hibarimicinone has been achieved. The polyhydroxydecalin moieties (AB and GH rings) have been synthesized from sulfonylenone 4 derived from d-arabinose. The chiral biaryl 20 was coupled with two polyhydroxydecalins 11 by Michael-Dieckmann type condensation to give the eight rings system. Aromatization and oxidation with Ag + gave quinone 24, and the subsequential transannular etheration gave the hibarimicinone skeleton. Deprotection and tautomerization were performed in one pot to give hibarimicinone (1).
| 元の言語 | English |
|---|---|
| ページ（範囲） | 422-425 |
| ページ数 | 4 |
| ジャーナル | Tetrahedron Letters |
| 巻 | 53 |
| 発行部数 | 4 |
| DOI | |
| 出版物ステータス | Published - 2012 1 25 |
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry
フィンガープリント The first total synthesis of hibarimicinone, a potent v-Src tyrosine kinase inhibitor' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。
これを引用
Tatsuta, K., Fukuda, T., Ishimori, T., Yachi, R., Yoshida, S., Hashimoto, H., & Hosokawa, S. (2012). The first total synthesis of hibarimicinone, a potent v-Src tyrosine kinase inhibitor. Tetrahedron Letters, 53(4), 422-425. https://doi.org/10.1016/j.tetlet.2011.11.062