The first total synthesis of lactonamycin, a hexacyclic antitumor antibiotic

Kuniaki Tatsuta, Hiroaki Tanaka, Hitomi Tsukagoshi, Takafumi Kashima, Seijiro Hosokawa

    研究成果: Article

    20 引用 (Scopus)

    抄録

    The total synthesis of lactonamycin has been achieved. The synthesis includes sequential intramolecular conjugate addition of alcohols to the acetylenic ester, stereoselective glycosylation of the tertiary alcohol, and Michael-Dieckmann type cyclization with the thioester, by which the highly convergent route has been established.

    元の言語English
    ページ(範囲)5546-5549
    ページ数4
    ジャーナルTetrahedron Letters
    51
    発行部数42
    DOI
    出版物ステータスPublished - 2010 10 20

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    Cyclization
    Glycosylation
    Esters
    Alcohols
    Anti-Bacterial Agents
    lactonamycin
    acetylenic alcohol

    ASJC Scopus subject areas

    • Biochemistry
    • Organic Chemistry
    • Drug Discovery

    これを引用

    The first total synthesis of lactonamycin, a hexacyclic antitumor antibiotic. / Tatsuta, Kuniaki; Tanaka, Hiroaki; Tsukagoshi, Hitomi; Kashima, Takafumi; Hosokawa, Seijiro.

    :: Tetrahedron Letters, 巻 51, 番号 42, 20.10.2010, p. 5546-5549.

    研究成果: Article

    Tatsuta, Kuniaki ; Tanaka, Hiroaki ; Tsukagoshi, Hitomi ; Kashima, Takafumi ; Hosokawa, Seijiro. / The first total synthesis of lactonamycin, a hexacyclic antitumor antibiotic. :: Tetrahedron Letters. 2010 ; 巻 51, 番号 42. pp. 5546-5549.
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