The first total synthesis of lactonamycin, a hexacyclic antitumor antibiotic

Kuniaki Tatsuta, Hiroaki Tanaka, Hitomi Tsukagoshi, Takafumi Kashima, Seijiro Hosokawa

研究成果: Article

23 引用 (Scopus)

抜粋

The total synthesis of lactonamycin has been achieved. The synthesis includes sequential intramolecular conjugate addition of alcohols to the acetylenic ester, stereoselective glycosylation of the tertiary alcohol, and Michael-Dieckmann type cyclization with the thioester, by which the highly convergent route has been established.

元の言語English
ページ(範囲)5546-5549
ページ数4
ジャーナルTetrahedron Letters
51
発行部数42
DOI
出版物ステータスPublished - 2010 10 20

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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