The first total synthesis of lactonamycin, a hexacyclic antitumor antibiotic

Kuniaki Tatsuta, Hiroaki Tanaka, Hitomi Tsukagoshi, Takafumi Kashima, Seijiro Hosokawa

研究成果: Article査読

26 被引用数 (Scopus)

抄録

The total synthesis of lactonamycin has been achieved. The synthesis includes sequential intramolecular conjugate addition of alcohols to the acetylenic ester, stereoselective glycosylation of the tertiary alcohol, and Michael-Dieckmann type cyclization with the thioester, by which the highly convergent route has been established.

本文言語English
ページ(範囲)5546-5549
ページ数4
ジャーナルTetrahedron Letters
51
42
DOI
出版ステータスPublished - 2010 10 20

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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