The fission yeast meiotic regulator Mei2p undergoes nucleocytoplasmic shuttling

Masamitsu Sato, Satoko Shinozaki-Yabana, Akira Yamashita, Yoshinori Watanabe, Masayuki Yamamoto

研究成果: Article

22 引用 (Scopus)

抄録

Schizosaccharomyces pombe Mei2p is an RNA-binding protein that switches the cell cycle from mitotic to meiotic. Mei2p forms a unique dot in the nucleus prior to meiosis I, aided by a non-coding RNA molecule termed meiRNA. Here we show that Mei2p intrinsically undergoes nucleocytoplasmic shuttling. Artificial acceleration of nuclear migration of Mei2p advances nuclear dot formation, but meiRNA does not appear to promote the dot formation by modulating the migration rate of Mei2p into the nucleus. Rather, this RNA is likely to facilitate the assembly of Mei2p into a dot structure and trap the protein as such in the nucleus.

元の言語English
ページ(範囲)251-255
ページ数5
ジャーナルFEBS Letters
499
発行部数3
DOI
出版物ステータスPublished - 2001 6 22
外部発表Yes

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Untranslated RNA
RNA-Binding Proteins
Schizosaccharomyces
Meiosis
Yeast
Cell Cycle
Cells
Switches
RNA
Molecules
Proteins

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

これを引用

Sato, M., Shinozaki-Yabana, S., Yamashita, A., Watanabe, Y., & Yamamoto, M. (2001). The fission yeast meiotic regulator Mei2p undergoes nucleocytoplasmic shuttling. FEBS Letters, 499(3), 251-255. https://doi.org/10.1016/S0014-5793(01)02567-4

The fission yeast meiotic regulator Mei2p undergoes nucleocytoplasmic shuttling. / Sato, Masamitsu; Shinozaki-Yabana, Satoko; Yamashita, Akira; Watanabe, Yoshinori; Yamamoto, Masayuki.

:: FEBS Letters, 巻 499, 番号 3, 22.06.2001, p. 251-255.

研究成果: Article

Sato, M, Shinozaki-Yabana, S, Yamashita, A, Watanabe, Y & Yamamoto, M 2001, 'The fission yeast meiotic regulator Mei2p undergoes nucleocytoplasmic shuttling', FEBS Letters, 巻. 499, 番号 3, pp. 251-255. https://doi.org/10.1016/S0014-5793(01)02567-4
Sato, Masamitsu ; Shinozaki-Yabana, Satoko ; Yamashita, Akira ; Watanabe, Yoshinori ; Yamamoto, Masayuki. / The fission yeast meiotic regulator Mei2p undergoes nucleocytoplasmic shuttling. :: FEBS Letters. 2001 ; 巻 499, 番号 3. pp. 251-255.
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