The G protein-coupled receptor family C group 6 subtype a (GPRC6A) receptor is involved in amino acid-induced glucagon-like peptide-1 secretion from GLUTag cells

Manami Oya, Tetsuya Kitaguchi, Ramona Pais, Frank Reimann, Fiona Gribble, Takashi Tsuboi

研究成果: Article

78 引用 (Scopus)

抜粋

Background: The molecular mechanisms underlying GLP-1 secretion induced by amino acids from intestinal L cells are not fully understood. Results: The L-amino acid-sensing GPRC6A receptor is expressed in the clonal L cell GLUTag. Activation of GPRC6A by L-ornithine evoked GLP-1 secretion. Conclusion: GLUTag cells respond to amino acids via the GPRC6A receptor. Significance: A new pathway for GLP-1 secretion induced by amino acids in GLUTag cells was identified.

元の言語English
ページ(範囲)4513-4521
ページ数9
ジャーナルJournal of Biological Chemistry
288
発行部数7
DOI
出版物ステータスPublished - 2013 2 15

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

フィンガープリント The G protein-coupled receptor family C group 6 subtype a (GPRC6A) receptor is involved in amino acid-induced glucagon-like peptide-1 secretion from GLUTag cells' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

  • これを引用