The human and mouse Period1 genes: Five well-conserved E-boxes additively contribute to the enhancement of mPer1 transcription

Akiko Hida, Nobuya Koike, Matsumi Hirose, Masahira Hattori, Yoshiyuki Sakaki, Hajime Tei*

*この研究の対応する著者

研究成果査読

122 被引用数 (Scopus)

抄録

The clock gene, Period1, from human and mouse was sequenced and characterized. Both human PERIOD1 (human PER1) and mouse Period1 (mouse Per1) consisted of 23 exons spanning approximately 16 kb, and their structures showed strong similarity to each other. For example, six highly conserved regions were identified in the 5' upstream sequences. These conserved segments exhibited 77-88% identity and possessed several potential regulatory elements including five E-boxes (the binding site of the CLOCKBMAL1 complex) and four cyclic AMP response elements. Transient transfection assays using a mPer1-luciferase fusion gene revealed that each of the conserved E-boxes additively functions as an enhancer for the transactivation of mPer1 by InCLOCK and mBMAL1. (C) Academic Press.

本文言語English
ページ(範囲)224-233
ページ数10
ジャーナルGenomics
65
3
DOI
出版ステータスPublished - 2000 5 1
外部発表はい

ASJC Scopus subject areas

  • 遺伝学

フィンガープリント

「The human and mouse Period1 genes: Five well-conserved E-boxes additively contribute to the enhancement of mPer1 transcription」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル