The mechanics of force generation by kinesin

J. Howard*, S. M. Block, G. F. Elliott, D. Hackney, K. Kinosita, D. Warshaw, R. D. Astumian

*この研究の対応する著者

研究成果: Article査読

17 被引用数 (Scopus)

抄録

Several laboratories have developed highly sensitive mechanical techniques for studying the movement of purified motor proteins along their associated filaments. The aim of these experiments is to test models for force generation, such as the powerstroke model and 'ratchet' or diffusional models, by 1) directly visualizing the path on the filament along which the motor moves, 2) measuring the force exerted by the motor against the filament, and 3) characterizing the passive mechanical properties (elasticity) of the motor. This paper focuses on recently published work on the microtubule-based motor kinesin taking this mechanical approach. Related work on myosin is mentioned for comparison.

本文言語English
ジャーナルBiophysical Journal
68
4 SUPPL.
出版ステータスPublished - 1995
外部発表はい

ASJC Scopus subject areas

  • 生物理学

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