The natural intron sequence of human tyrosine pre-transfer RNA is not a temporal stabilizer for cloverleaf structure

Tomoaki Ando, Terumichi Tanaka, Yo Kikuchi

研究成果: Article査読

抄録

We have developed the hyperprocessing technique to evaluate the stability of the cloverleaf shape of pretransfer RNA (pre-tRNA). Application of this strategy to hyperprocessible human tyrosine pre-tRNA indicated that the natural intron sequence did not contribute to stabilization of the cloverleaf shape of this pre-tRNA, while the artificial intron with elongated anticodon-stem completely inhibited hyperprocessing of it. Our data suggested that the contemporary intron sequence may be a vestige of the ancient pre-biotic world, but not has been retained as a temporal stabilizer of the pre-tRNA before the base modifications.

本文言語English
ページ(範囲)1782-1785
ページ数4
ジャーナルBioscience, Biotechnology and Biochemistry
68
8
DOI
出版ステータスPublished - 2004 8
外部発表はい

ASJC Scopus subject areas

  • 食品科学
  • 応用微生物学とバイオテクノロジー
  • 化学(その他)
  • 生化学、遺伝学、分子生物学(全般)
  • 生化学
  • バイオテクノロジー

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