The nucleosome: a powerful regulator of transcription.

A. P. Wolffe*, H. Kurumizaka

*この研究の対応する著者

研究成果: Article査読

93 被引用数 (Scopus)

抄録

Nucleosomes provide the architectural framework for transcription. Histones, DNA elements, and transcription factors are organized into precise regulatory complexes. Positioned nucleosomes can facilitate or impede the transcription process. These structures are dynamic, reflecting the capacity of chromatin to adopt different functional states. Histones are mobile with respect to DNA sequence. Individual histone domains are targeted for posttranslational modifications. Histone acetylation promotes transcription factor access to nucleosomal DNA and relieves inhibitory effects on transcriptional initiation and elongation. The nucleosomal infrastructure emerges as powerful contributor to the regulation of gene activity.

本文言語English
ページ(範囲)379-422
ページ数44
ジャーナルProgress in Nucleic Acid Research and Molecular Biology
61
出版ステータスPublished - 1998
外部発表はい

ASJC Scopus subject areas

  • 分子生物学

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