The Prognostic Impact of Pretransplantation Inflammatory and Nutritional Status in Adult Patients after Myeloablative Single Cord Blood Transplantation

Eita Miyashita, Takaaki Konuma, Jun Kataoka, Maki Oiwa-Monna, Mai Mizusawa, Masamichi Isobe, Seiko Kato, Tomoko Sato, Satoshi Takahashi, Arinobu Tojo

研究成果: Article

2 引用 (Scopus)

抄録

Markers of inflammatory and nutritional status, such as the Controlling Nutritional Status (CONUT) score, Prognostic Nutritional Index, Glasgow Prognostic Score, and C-reactive protein-albumin ratio (CAR) has been demonstrated to be associated with poor prognosis in patients with various cancers. Although the relatively low cell dose of a single cord blood unit restricts the indication for cord blood transplantation (CBT) to pediatric and relatively smaller and lighter adult patients, the impact of malnutrition on outcomes after CBT is unclear. We retrospectively analyzed 165 adult patients who underwent myeloablative single-unit CBT in our institute. In multivariate analysis, a higher CONUT score, which is indicative of poor inflammatory and nutritional status, was significantly associated with poor outcomes, including low neutrophil engraftment and development of extensive chronic graft-versus-host disease. A higher CAR, which is also suggestive of poor inflammatory and nutritional status, was significantly associated with poor neutrophil engraftment and higher overall mortality. Body mass index (BMI) was not associated with transplantation outcomes. These data suggest that poor pretransplantation inflammatory and nutritional status might be a more practical parameter than lower BMI, for predicting transplantation outcomes after single CBT for adults.

元の言語English
ジャーナルBiology of Blood and Marrow Transplantation
DOI
出版物ステータスPublished - 2019 1 1
外部発表Yes

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Nutritional Status
Fetal Blood
Transplantation
C-Reactive Protein
Albumins
Body Mass Index
Neutrophils
Nutrition Assessment
Graft vs Host Disease
Malnutrition
Multivariate Analysis
Pediatrics
Mortality
Neoplasms

ASJC Scopus subject areas

  • Hematology
  • Transplantation

これを引用

The Prognostic Impact of Pretransplantation Inflammatory and Nutritional Status in Adult Patients after Myeloablative Single Cord Blood Transplantation. / Miyashita, Eita; Konuma, Takaaki; Kataoka, Jun; Oiwa-Monna, Maki; Mizusawa, Mai; Isobe, Masamichi; Kato, Seiko; Sato, Tomoko; Takahashi, Satoshi; Tojo, Arinobu.

:: Biology of Blood and Marrow Transplantation, 01.01.2019.

研究成果: Article

Miyashita, Eita ; Konuma, Takaaki ; Kataoka, Jun ; Oiwa-Monna, Maki ; Mizusawa, Mai ; Isobe, Masamichi ; Kato, Seiko ; Sato, Tomoko ; Takahashi, Satoshi ; Tojo, Arinobu. / The Prognostic Impact of Pretransplantation Inflammatory and Nutritional Status in Adult Patients after Myeloablative Single Cord Blood Transplantation. :: Biology of Blood and Marrow Transplantation. 2019.
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abstract = "Markers of inflammatory and nutritional status, such as the Controlling Nutritional Status (CONUT) score, Prognostic Nutritional Index, Glasgow Prognostic Score, and C-reactive protein-albumin ratio (CAR) has been demonstrated to be associated with poor prognosis in patients with various cancers. Although the relatively low cell dose of a single cord blood unit restricts the indication for cord blood transplantation (CBT) to pediatric and relatively smaller and lighter adult patients, the impact of malnutrition on outcomes after CBT is unclear. We retrospectively analyzed 165 adult patients who underwent myeloablative single-unit CBT in our institute. In multivariate analysis, a higher CONUT score, which is indicative of poor inflammatory and nutritional status, was significantly associated with poor outcomes, including low neutrophil engraftment and development of extensive chronic graft-versus-host disease. A higher CAR, which is also suggestive of poor inflammatory and nutritional status, was significantly associated with poor neutrophil engraftment and higher overall mortality. Body mass index (BMI) was not associated with transplantation outcomes. These data suggest that poor pretransplantation inflammatory and nutritional status might be a more practical parameter than lower BMI, for predicting transplantation outcomes after single CBT for adults.",
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AU - Miyashita, Eita

AU - Konuma, Takaaki

AU - Kataoka, Jun

AU - Oiwa-Monna, Maki

AU - Mizusawa, Mai

AU - Isobe, Masamichi

AU - Kato, Seiko

AU - Sato, Tomoko

AU - Takahashi, Satoshi

AU - Tojo, Arinobu

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KW - Cord blood transplantation

KW - CRP-albumin ratio

KW - Glasgow Prognostic Score

KW - Prognostic nutritional index

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