The recognition of protein structure and function from sequence

adding value to genome data.

A. C. May, M. S. Johnson, S. D. Rufino, Hiroshi Wako, Z. Y. Zhu, R. Sowdhamini, N. Srinivasan, M. A. Rodionov, T. L. Blundell

研究成果: Article

15 引用 (Scopus)

抄録

The explosion of DNA sequence data from genome projects presents many challenges. For instance, we must extend our current knowledge of protein structure and function so that it can be applied to these new sequences. The derivation of rules for the relationships between sequence and structure allow us to recognize a common fold by the use of tertiary templates. New techniques enable us to begin to meet the challenge of rule-based modelling of distantly related proteins. This paper describes an integrated and knowledge-based approach to the prediction of protein structure and function which can maximize the value of sequence information.

元の言語English
ページ(範囲)373-381
ページ数9
ジャーナルPhilosophical transactions of the Royal Society of London. Series B: Biological sciences
344
発行部数1310
出版物ステータスPublished - 1994 6 29
外部発表Yes

Fingerprint

protein structure
genome
Genes
Genome
protein
explosions
Proteins
Explosions
DNA sequences
nucleotide sequences
prediction
explosion
fold
DNA
proteins
modeling
methodology

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Agricultural and Biological Sciences (miscellaneous)

これを引用

The recognition of protein structure and function from sequence : adding value to genome data. / May, A. C.; Johnson, M. S.; Rufino, S. D.; Wako, Hiroshi; Zhu, Z. Y.; Sowdhamini, R.; Srinivasan, N.; Rodionov, M. A.; Blundell, T. L.

:: Philosophical transactions of the Royal Society of London. Series B: Biological sciences, 巻 344, 番号 1310, 29.06.1994, p. 373-381.

研究成果: Article

May, AC, Johnson, MS, Rufino, SD, Wako, H, Zhu, ZY, Sowdhamini, R, Srinivasan, N, Rodionov, MA & Blundell, TL 1994, 'The recognition of protein structure and function from sequence: adding value to genome data.', Philosophical transactions of the Royal Society of London. Series B: Biological sciences, 巻. 344, 番号 1310, pp. 373-381.
May, A. C. ; Johnson, M. S. ; Rufino, S. D. ; Wako, Hiroshi ; Zhu, Z. Y. ; Sowdhamini, R. ; Srinivasan, N. ; Rodionov, M. A. ; Blundell, T. L. / The recognition of protein structure and function from sequence : adding value to genome data. :: Philosophical transactions of the Royal Society of London. Series B: Biological sciences. 1994 ; 巻 344, 番号 1310. pp. 373-381.
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