The recognition of protein structure and function from sequence: adding value to genome data.

A. C. May, M. S. Johnson, S. D. Rufino, H. Wako, Z. Y. Zhu, R. Sowdhamini, N. Srinivasan, M. A. Rodionov, T. L. Blundell

研究成果: Review article査読

16 被引用数 (Scopus)

抄録

The explosion of DNA sequence data from genome projects presents many challenges. For instance, we must extend our current knowledge of protein structure and function so that it can be applied to these new sequences. The derivation of rules for the relationships between sequence and structure allow us to recognize a common fold by the use of tertiary templates. New techniques enable us to begin to meet the challenge of rule-based modelling of distantly related proteins. This paper describes an integrated and knowledge-based approach to the prediction of protein structure and function which can maximize the value of sequence information.

本文言語English
ページ(範囲)373-381
ページ数9
ジャーナルPhilosophical transactions of the Royal Society of London. Series B, Biological sciences
344
1310
DOI
出版ステータスPublished - 1994 6 29
外部発表はい

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

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